Our analysis provides guidelines for a quantitative network analysis of antibody repertoires, which can be applied to other facets of adaptive immunity (e.g., T cell receptors), and may direct the construction of synthetic repertoires for biomedical applications. 2005), directly impacting on the peripheral T cell repertoire and. Redundancy in mutational pathways suggests that there is a pre-programmed evolvability in antibody repertoires. Age-dependent regression of the thymus, thymic atrophy, defined as the loss of thymic. Robustness ensures a functional immune response even under extensive loss of clones (50%). By identifying shared motifs in core sequences, we were able to highlight key conserved residues driving essential elements of TCR recognition. Reproducibility of network structure explains clonal expansion and selection. Our analyses demonstrate that each epitope-specific repertoire contains a clustered group of receptors that share core sequence similarities, together with a dispersed set of diverse 'outlier' sequences. repertoire synonyms, repertoire pronunciation, repertoire translation, English dictionary definition of repertoire. We identified three fundamental principles of antibody repertoire architecture across B-cell development: reproducibility, robustness and redundancy. Bibliography of the History of Art (BHA) and Rpertoire international de la. As the repertoire shapes and represents immunological. Multidisciplinary, including area studies, astronomy, biology, chemistry. Here, we established a novel high-performance computing platform to construct large-scale networks from high-throughput sequencing data (>100’000 unique antibodies), in order to uncover the architecture of antibody repertoires. an immunoglobulin molecule having a specific amino acid sequence that gives each antibody the ability to adhere to and interact only with the antigen that. Immune repertoire is a collection of enormously diverse adaptive immune cells within an individual.
The architecture of the antibody repertoire, defined by the network similarity landscape of its sequences, is unknown. measuring a limited but well-defined repertoire of behaviors. The antibody repertoire is a vast and diverse collection of B-cell receptors and antibodies that confer protection against a plethora of pathogens. The biological study of animal behavior, including its phenom.
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